PDBsum entry 7bnc

Hydrolase

PDB id: 7bnc

Contents

Protein chain

353 a.a.

Ligands

SO4 ×7

GOL

NAG

U5B

Waters ×46

PDB id:

7bnc

Name:

Hydrolase

Title:

Notum fragment_126 (2-(1,2-dihydroacenaphthylen-5-ylsulfanyl)acetic acid)

Structure:

Palmitoleoyl-protein carboxylesterase notum. Chain: a. Synonym: hnotum. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notum, ok/sw-cl.30. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

1.86Å R-factor: 0.207 R-free: 0.244

Authors:

Y.Zhao,E.Y.Jones

Key ref:

Y.Zhao and e.y.jones Notum inhibitor. To be published, .

Date:

21-Jan-21 Release date: 02-Mar-22

Protein chain

Q6P988  (NOTUM_HUMAN) -  Palmitoleoyl-protein carboxylesterase NOTUM from Homo sapiens

Seq: 496 a.a.

Struc: 353 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
• Reaction: [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = [Wnt protein]-L-serine + (9Z)-hexadecenoate + H⁺