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PDBsum entry 7bfs
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PDB id:
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DNA
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Title:
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Deoxyxylose nucleic acid hairpin
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Structure:
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DNA (5'-d( Ap Gp Cp Ap Ap Tp Cp Cp (Xc)p (Xc)p (Xc)p (Xc) p Gp Gp Ap Tp Tp Gp Cp T)-3'). Chain: a. Engineered: yes
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Source:
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Synthetic: yes. Escherichia coli. Organism_taxid: 562. Other_details: cruciform cole1
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NMR struc:
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10 models
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Authors:
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C.-A.Mattelaer,M.Mohitosh,L.Smets,M.Maiti,G.Schepers,H.-P.Mattelaer, H.Rosemeyer,P.Herdewijn,E.Lescrinier
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Key ref:
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C.A.Mattelaer
et al.
(2021).
Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.
Chembiochem,
22,
1638-1645.
PubMed id:
DOI:
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Date:
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04-Jan-21
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Release date:
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27-Jan-21
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Headers
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References
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A-G-C-A-A-T-C-C-_XC-_XC-_XC-_XC-G-G-A-T-T-G-C-T
20 bases
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DOI no:
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Chembiochem
22:1638-1645
(2021)
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PubMed id:
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Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.
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C.A.Mattelaer,
M.Maiti,
L.Smets,
M.Maiti,
G.Schepers,
H.P.Mattelaer,
H.Rosemeyer,
P.Herdewijn,
E.Lescrinier.
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ABSTRACT
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Xenobiology explores synthetic nucleic acid polymers as alternative carriers of
genetic information to expand the central dogma. The xylo- and deoxyxylo-nucleic
acids (XyNA and dXyNA), containing 3' epimers of riboses and deoxyriboses, are
considered to be potential candidates for an orthogonal system. In this study,
thermal and spectroscopic analyses show that XyNA and dXyNA form stable
hairpins. The dXyNA hairpin structure determined by NMR spectroscopy contains a
flexible loop that locks the stem into a stable ladder-like duplex with marginal
right-handed helicity. The reduced flexibility of the dXyNA duplex observed in
the stem of the hairpin demonstrates that folding of dXyNA yields more stable
structures described so far.
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Links
