PDBsum entry 7bac

Hydrolase

PDB id: 7bac

Contents

Protein chain

352 a.a.

Ligands

SO4 ×5

NAG

DMS

LO5 ×2

Waters ×105

PDB id:

7bac

Name:

Hydrolase

Title:

Notum fragment 646

Structure:

Palmitoleoyl-protein carboxylesterase notum. Chain: a. Synonym: hnotum. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notum, ok/sw-cl.30. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

1.54Å R-factor: 0.213 R-free: 0.248

Authors:

Y.Zhao,E.Y.Jones

Key ref:

e.y.jones and p.fish (2022). Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2060-2077. PubMed id: 35731924

Date:

15-Dec-20 Release date: 12-Jan-22

Protein chain

Q6P988  (NOTUM_HUMAN) -  Palmitoleoyl-protein carboxylesterase NOTUM from Homo sapiens

Seq: 496 a.a.

Struc: 352 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
• Reaction: [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = [Wnt protein]-L-serine + (9Z)-hexadecenoate + H⁺

Acs Chem Neurosci 13:2060-2077 (2022)

PubMed id: 35731924

Structural Analysis and Development of Notum Fragment Screening Hits.

e.y.jones, p.fish.

ABSTRACT

No abstract given.