PDBsum entry 7b45

Hydrolase

PDB id: 7b45

Contents

Protein chain

344 a.a.

Ligands

NAG

SO4 ×7

DMS ×3

EDO

SWQ

Waters ×111

PDB id:

7b45

Name:

Hydrolase

Title:

Notum complex with aruk3003934

Structure:

Palmitoleoyl-protein carboxylesterase notum. Chain: a. Synonym: hnotum. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notum, ok/sw-cl.30. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

1.38Å R-factor: 0.190 R-free: 0.194

Authors:

P.Fish,E.Y.Jones

Key ref:

P.Fish and e.y.jones Notum inhibitor. To be published, . PubMed id: 34939789

Date:

02-Dec-20 Release date: 12-Jan-22

Protein chain

Q6P988  (NOTUM_HUMAN) -  Palmitoleoyl-protein carboxylesterase NOTUM from Homo sapiens

Seq: 496 a.a.

Struc: 344 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
• Reaction: [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = [Wnt protein]-L-serine + (9Z)-hexadecenoate + H⁺