PDBsum entry 7axc

Nuclear protein

PDB id: 7axc

Contents

Protein chain

264 a.a.

Ligands

27H

GOL

IPA ×4

Waters ×132

PDB id:

7axc

Name:

Nuclear protein

Title:

Crystal structure of the hpxr-lbd in complex with ferutinine

Structure:

Nuclear receptor subfamily 1 group i member 2. Chain: a. Synonym: orphan nuclear receptor par1,orphan nuclear receptor pxr, pregnane x receptor,steroid and xenobiotic receptor,sxr. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nr1i2, pxr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.05Å R-factor: 0.207 R-free: 0.251

Authors:

M.Granell,V.Delfosse,W.Bourguet

Key ref:

V.Delfosse et al. (2021). Mechanistic insights into the synergistic activation rxr-Pxr heterodimer by endocrine disruptor mixtures.. Proc natl acad sci usa, 118, . PubMed id: 33361153

Date:

09-Nov-20 Release date: 13-Jan-21

Protein chain

O75469  (NR1I2_HUMAN) -  Nuclear receptor subfamily 1 group I member 2 from Homo sapiens

Seq: 434 a.a.

Struc: 264 a.a.

Enzyme reactions

• Enzyme class: E.C.?