PDBsum entry 7ad6

Immune system

PDB id: 7ad6

Contents

Protein chains

971 a.a.

646 a.a.

34 a.a.

Ligands

NAG-NAG-BMA

EDO ×3

CYS

TRS

Waters ×12

PDB id:

7ad6

Name:

Immune system

Title:

Crystal structure of human complement c5 in complex with the k92 bovine knob domain peptide.

Structure:

Complement c5. Chain: a, b. Synonym: c3 and pzp-like alpha-2-macroglobulin domain-containing protein 4. K92 knob domain. Chain: c. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Bos taurus. Organism_taxid: 9913. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293

Resolution:

2.75Å R-factor: 0.221 R-free: 0.254

Authors:

A.Macpherson,J.M.H.Van Den Elsen,M.E.Schulze,J.R.Birtley

Key ref:

A.Macpherson et al. (2021). The allosteric modulation of complement c5 by knob do peptides.. Elife, 10, . PubMed id: 33570492

Date:

14-Sep-20 Release date: 10-Mar-21

Protein chain

P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens

Seq: 1676 a.a.

Struc: 971 a.a.

Protein chain

P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens

Seq: 1676 a.a.

Struc: 646 a.a.

Protein chain

No UniProt id for this chain

Struc: 34 a.a.