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PDBsum entry 7acf
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Signaling protein
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PDB id
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7acf
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Crystal structure of crystal form 2 of an active kras g12d (gppcp) dimer in complex with bi-5747
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Structure:
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Gtpase kras. Chain: a, b, c, d. Synonym: k-ras 2,ki-ras,c-k-ras,c-ki-ras. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: kras, kras2, rask2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.91Å
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R-factor:
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0.187
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R-free:
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0.198
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Authors:
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D.Kessler
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Key ref:
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D.Kessler
et al.
(2020).
Reply to tran et al.: Dimeric kras protein-Protein interaction stabilizers..
Proc natl acad sci,
117,
3365.
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Date:
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10-Sep-20
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Release date:
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18-Nov-20
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PROCHECK
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Headers
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References
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P01116
(RASK_HUMAN) -
GTPase KRas from Homo sapiens
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Seq:
Struc:
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189 a.a.
169 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 7 residue positions (black
crosses)
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Enzyme class:
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E.C.3.6.5.2
- small monomeric GTPase.
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Reaction:
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GTP + H2O = GDP + phosphate + H+
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GTP
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+
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H2O
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=
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GDP
Bound ligand (Het Group name = )
matches with 81.82% similarity
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
