PDBsum entry 7abh

Splicing

PDB id: 7abh

Contents

Protein chains

48 a.a.

100 a.a.

75 a.a.

108 a.a.

932 a.a.

183 a.a.

1177 a.a.

78 a.a.

79 a.a.

108 a.a.

150 a.a.

122 a.a.

95 a.a.

33 a.a.

DNA/RNA

PDB id:

7abh

Name:

Splicing

Title:

Human pre-bact-2 spliceosome (sf3b/u2 snrnp portion)

Structure:

Cell division cycle 5-like protein. Chain: l. Synonym: cdc5-like protein,pombe cdc5-related protein. Phd finger-like domain-containing protein 5a. Chain: y. Synonym: phd finger-like domain protein 5a,splicing factor 3b- associated 14 kda protein,sf3b14b. Minx m3 pre-mRNA. Chain: z.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Cell_line: hela. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Cell_line: hela

Authors:

C.Townsend,B.Kastner,M.N.Leelaram,K.Bertram,H.Stark,R.Luehrmann

Key ref:

C.Townsend et al. Mechanism of protein-Guided folding of the active sit RNA during spliceosome activation.. Science, . PubMed id: 33243851

Date:

07-Sep-20 Release date: 09-Dec-20

Protein chain

Q99459  (CDC5L_HUMAN) -  Cell division cycle 5-like protein from Homo sapiens

Seq: 802 a.a.

Struc: 48 a.a.

Protein chain

Q7RTV0  (PHF5A_HUMAN) -  PHD finger-like domain-containing protein 5A from Homo sapiens

Seq: 110 a.a.

Struc: 100 a.a.

Protein chain

Q15428  (SF3A2_HUMAN) -  Splicing factor 3A subunit 2 from Homo sapiens

Seq: 464 a.a.

Struc: 75 a.a.

Protein chain

Q12874  (SF3A3_HUMAN) -  Splicing factor 3A subunit 3 from Homo sapiens

Seq: 501 a.a.

Struc: 108 a.a.

Protein chain

O75533  (SF3B1_HUMAN) -  Splicing factor 3B subunit 1 from Homo sapiens

Seq: 1304 a.a.

Struc: 932 a.a.*

Protein chain

Q13435  (SF3B2_HUMAN) -  Splicing factor 3B subunit 2 from Homo sapiens

Seq: 895 a.a.

Struc: 183 a.a.*

Protein chain

Q15393  (SF3B3_HUMAN) -  Splicing factor 3B subunit 3 from Homo sapiens

Seq: 1217 a.a.

Struc: 1177 a.a.

Protein chain

Q15427  (SF3B4_HUMAN) -  Splicing factor 3B subunit 4 from Homo sapiens

Seq: 424 a.a.

Struc: 78 a.a.

Protein chain

Q9BWJ5  (SF3B5_HUMAN) -  Splicing factor 3B subunit 5 from Homo sapiens

Seq: 86 a.a.

Struc: 79 a.a.

Protein chain

Q9Y3B4  (SF3B6_HUMAN) -  Splicing factor 3B subunit 6 from Homo sapiens

Seq: 125 a.a.

Struc: 108 a.a.

Protein chain

Q8TAD8  (SNIP1_HUMAN) -  Smad nuclear-interacting protein 1 from Homo sapiens

Seq: 396 a.a.

Struc: 150 a.a.

Protein chain

Q9Y388  (RBMX2_HUMAN) -  RNA-binding motif protein, X-linked 2 from Homo sapiens

Seq: 322 a.a.

Struc: 122 a.a.

Protein chain

Q8IYB3  (SRRM1_HUMAN) -  Serine/arginine repetitive matrix protein 1 from Homo sapiens

Seq: 904 a.a.

Struc: 95 a.a.

Protein chain

O60870  (KIN17_HUMAN) -  DNA/RNA-binding protein KIN17 from Homo sapiens

Seq: 393 a.a.

Struc: 33 a.a.

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

DNA/RNA chains

A-U-G-A-U-G-U-C-A-U-A-C-U-U-A-U-C-C-U-G-U-C-C-C-U-U-U-U 28 bases

A-A-G-U-G-U-A-G-U-A-U-C-U-G-U-U-C-U-U-A-U-C-A-G-U-U-U-A-A-U-A-U-C-U-G-A-U 37 bases