PDBsum entry 7a7c

Metal binding protein

PDB id: 7a7c

Contents

Protein chains

560 a.a.

666 a.a.

Ligands

HEM

PDB id:

7a7c

Name:

Metal binding protein

Title:

Cryo-em structure of w107r after heme uptake (1heme molecule) katg from m. Tuberculosis

Structure:

Catalase-peroxidase. Chain: a, b. Synonym: cp,peroxidase/catalase. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: katg, ers007661_00994, ers013471_02729, ers024276_01596, ers075361_01376, ers094182_01139, f6w99_00474, frd82_12135. Expressed in: escherichia coli. Expression_system_taxid: 562

Authors:

T.L.Blundell,A.K.Chaplin,A.Munir

Key ref:

A.Munir et al. Using cryo-Em to understand antimycobacterial resista the catalase-Peroxidase (katg) from mycobacterium tuberculosis.. Structure, . PubMed id: 33444527

Date:

27-Aug-20 Release date: 27-Jan-21

Protein chain

P9WIE5  (KATG_MYCTU) -  Catalase-peroxidase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 740 a.a.

Struc: 560 a.a.*

Protein chain

P9WIE5  (KATG_MYCTU) -  Catalase-peroxidase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 740 a.a.

Struc: 666 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.1.11.1.21 - catalase peroxidase.
• Reaction:
  1. H2O2 + AH2 = A + 2 H2O
  2. 2 H2O2 = O2 + 2 H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site