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PDBsum entry 6zrv
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PDB id:
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Hydrolase
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Title:
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Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-w175f) in complex with an inhibitory nanobody (vhh-s-a93, nb93)
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Structure:
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Plasminogen activator inhibitor 1. Chain: a. Synonym: pai-1,endothelial plasminogen activator inhibitor,serpin e1. Engineered: yes. Mutation: yes. Vhh-s-a93 (nb93). Chain: b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: serpine1, pai1, planh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta 2(de3)plyss. Vicugna pacos. Alpaca.
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Resolution:
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1.88Å
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R-factor:
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0.198
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R-free:
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0.233
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Authors:
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M.Sillen,S.D.Weeks,S.V.Strelkov,P.J.Declerck
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Key ref:
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m.sillen
et al.
(2020).
Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Int J Mol Sci,
21,
.
PubMed id:
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Date:
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15-Jul-20
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Release date:
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26-Aug-20
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PROCHECK
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Headers
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References
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Int J Mol Sci
21:
(2020)
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PubMed id:
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Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
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m.sillen,
s.d.weeks,
s.v.strelkov,
p.j.declerck.
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ABSTRACT
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Links
