 |
PDBsum entry 6zfs
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Electron transport
|
PDB id
|
|
|
|
6zfs
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
441 a.a.
|
|
|
|
|
|
|
|
|
|
|
415 a.a.
|
|
|
|
|
|
|
|
|
|
|
378 a.a.
|
|
|
|
|
|
|
|
|
|
|
239 a.a.
|
|
|
|
|
|
|
|
|
|
|
195 a.a.
|
|
|
|
|
|
|
|
|
|
|
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
75 a.a.
|
|
|
|
|
|
|
|
|
|
|
64 a.a.
|
|
|
|
|
|
|
|
|
|
|
46 a.a.
|
|
|
|
|
|
|
|
|
|
|
59 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Electron transport
|
|
|
Title:
|
|
Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor wdh-1u-4
|
|
Structure:
|
|
Cytochrome b-c1 complex subunit 1, mitochondrial. Chain: a. Synonym: complex iii subunit 1,core protein i,ubiquinol-cytochromE-C reductase complex core protein 1. Cytochrome b-c1 complex subunit 2, mitochondrial. Chain: b. Synonym: complex iii subunit 2,core protein ii,ubiquinol-cytochromE-C reductase complex core protein 2. Cytochrome b.
|
|
Source:
|
|
Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
|
|
Resolution:
|
|
|
3.50Å
|
R-factor:
|
0.219
|
R-free:
|
0.246
|
|
|
Authors:
|
|
K.Amporndanai,P.M.O'Neill,W.D.Hong,R.K.Amewu,C.Pidathala,N.G.Berry, G.A.Biagini,S.C.Leung,S.S.Hasnain,S.V.Antonyuk
|
|
Key ref:
|
|
K.Amporndanai
et al.
Targeting the ubiquinol-Reduction (qi) site of the mitochondrial cytochrome bc1 complex for the developm next generation quinolone antimalarials.
To be published,
.
|
|
|
Date:
|
|
|
17-Jun-20
|
Release date:
|
30-Jun-21
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P31800
(QCR1_BOVIN) -
Cytochrome b-c1 complex subunit 1, mitochondrial from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
480 a.a.
441 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P23004
(QCR2_BOVIN) -
Cytochrome b-c1 complex subunit 2, mitochondrial from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
453 a.a.
415 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P00157
(CYB_BOVIN) -
Cytochrome b from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
379 a.a.
378 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P00125
(CY1_BOVIN) -
Cytochrome c1, heme protein, mitochondrial from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
325 a.a.
239 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P13272
(UCRI_BOVIN) -
Cytochrome b-c1 complex subunit Rieske, mitochondrial from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
274 a.a.
195 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P00129
(QCR7_BOVIN) -
Cytochrome b-c1 complex subunit 7 from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
111 a.a.
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P13271
(QCR8_BOVIN) -
Cytochrome b-c1 complex subunit 8 from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
82 a.a.
75 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P00126
(QCR6_BOVIN) -
Cytochrome b-c1 complex subunit 6, mitochondrial from Bos taurus
|
|
|
|
Seq:
Struc:
|
|
|
|
91 a.a.
64 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class 2:
|
|
Chains A, B, C, F, G, H, J:
E.C.?
|
|
|
|
|
|
|
Enzyme class 3:
|
|
Chains D, E, I:
E.C.7.1.1.8
- quinol--cytochrome-c reductase.
|
|
|
|
|
|
|
Reaction:
|
|
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)- [cytochrome c](out) + 2 H(+)(out)
|
|
|
|
|
|
quinol
|
+
|
2
×
Fe(III)-[cytochrome c](out)
|
=
|
quinone
|
+
|
2
×
Fe(II)- [cytochrome c](out)
|
+
|
2
×
H(+)(out)
|
|
|
|
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
| | |
Links
