PDBsum entry 6zcs

Transferase

PDB id: 6zcs

Contents

Protein chain

269 a.a.

Ligands

QFE

Waters ×350

PDB id:

6zcs

Name:

Transferase

Title:

Syk kinase domain in complex with azabenzimidazole inhibitor 3

Structure:

Tyrosine-protein kinase syk. Chain: a. Synonym: spleen tyrosine kinase,p72-syk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.47Å R-factor: 0.191 R-free: 0.208

Authors:

J.A.Read

Key ref:

J.A.Read Syk kinase domain in complex with azabenzimidazole in 3. To be published, .

Date:

12-Jun-20 Release date: 23-Jun-21

Protein chain

P43405  (KSYK_HUMAN) -  Tyrosine-protein kinase SYK from Homo sapiens

Seq: 635 a.a.

Struc: 269 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site