PDBsum entry 6yyc

Ligase

PDB id

6yyc

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Contents

			Protein chain

					295 a.a.

			Ligands

					Q0Z


					SO4


					EDO

			Waters ×290

PDB id:

6yyc

Links

Name:

Ligase

Title:

Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor

Structure:

Phosphoribosylaminoimidazole-succinocarboxamide synthase. Chain: a. Synonym: saicar synthetase. Engineered: yes

Source:

Mycobacteroides abscessus (strain atcc 19977 / dsm 44196 / cip 104536 / jcm 13569 / nctc 13031 / tmc 1543). Organism_taxid: 561007. Strain: atcc 19977 / dsm 44196 / cip 104536 / jcm 13569 / nctc 13031 / tmc 1543. Gene: purc, mab_0689. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.27Å

R-factor:

0.224

R-free:

0.256

Authors:

S.E.Thomas,S.Charoensutthivarakul,A.G.Coyne,C.Abell,T.L.Blundell

Date:

04-May-20

Release date:

12-May-21

PROCHECK

	Headers

	References

Protein chain

B1MHW4 (PUR7_MYCA9) - Phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948)

Seq: Struc:					297 a.a. 295 a.a.

Key:

PfamA domain

Secondary structure



		Enzyme reactions

Enzyme class:

E.C.6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Purine Biosynthesis (late stages)

Reaction:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4- carboxamido]succinate + ADP + phosphate + 2 H⁺

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate	+	L-aspartate	+	ATP	=	(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4- carboxamido]succinate	+	ADP	+	phosphate	+	2 × H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site