PDBsum entry 6yjs

Transferase

PDB id: 6yjs

Contents

Protein chains

470 a.a.

Ligands

EDO ×11

NAG ×2

SO4 ×10

• PDB id:

  6yjs

• Name: Transferase
• Title: Crystal structure of mgat5 (alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase v) luminal domain with a lys329-ile345 loop truncation, in complex with biantennary pentasaccharide m592
• Source: Homo sapiens
• Authors: not given
• Date:

  2020-04-0

Protein chains

Q09328  (MGT5A_HUMAN) -  Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A from Homo sapiens

Seq: 741 a.a.

Struc: 470 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.4.1.155 - alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase.
• Pathway: Mannosyl-glycoprotein N-acetylglucosaminyltransferases
• Reaction: N₄-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)- [beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = N₄-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]- alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D- Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L- asparaginyl-[protein] + UDP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site