PDBsum entry 6yf3

Isomerase

PDB id: 6yf3

Contents

Protein chain

108 a.a.

Ligands

OOZ

Metals

_NA

_CD

_CL ×2

Waters ×142

PDB id:

6yf3

Name:

Isomerase

Title:

Fkbp12 in complex with the bmp potentiator compound 10 at 1.00a resolution

Structure:

Peptidyl-prolyl cis-trans isomerase fkbp1a. Chain: a. Synonym: ppiase fkbp1a,12 kda fk506-binding protein,fkbp-12, calstabin-1,fk506-binding protein 1a,fkbp-1a,immunophilin fkbp12, rotamase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

1.00Å R-factor: 0.157 R-free: 0.158

Authors:

J.Kallen

Key ref:

m.h.larraufie et al. (2021). Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 0, . PubMed id: 33894161

Date:

25-Mar-20 Release date: 10-Mar-21

Protein chain

P62942  (FKB1A_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1A from Homo sapiens

Seq: 108 a.a.

Struc: 108 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Cell Chem Biol 0: (2021)

PubMed id: 33894161

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

m.h.larraufie, x.gao, x.xia, p.j.devine, d.liu, a.harsch, j.kallen, n.savage, j.ding, k.tan, m.mihalic, p.krastel, g.michaud, m.salcius, a.izaac, j.gao, f.harbinski, s.roggos.canham, s.bushell, e.altinoglu, p.lustenberger, e.willic.fryer, f.cong, l.klickstein, j.tallarico, r.jain, d.m.ros.wang.

ABSTRACT

No abstract given.