PDBsum entry 6yf1

Isomerase

PDB id: 6yf1

Contents

Protein chain

107 a.a.

Ligands

OP8

Waters ×170

PDB id:

6yf1

Name:

Isomerase

Title:

Fkbp12 in complex with the bmp potentiator compound 8 at 1.12a resolution

Structure:

Peptidyl-prolyl cis-trans isomerase fkbp1a. Chain: a. Synonym: ppiase fkbp1a,12 kda fk506-binding protein,fkbp-12, calstabin-1,fk506-binding protein 1a,fkbp-1a,immunophilin fkbp12, rotamase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

1.12Å R-factor: 0.156 R-free: 0.163

Authors:

J.Kallen

Key ref:

m.h.larraufie et al. (2021). Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 0, . PubMed id: 33894161

Date:

25-Mar-20 Release date: 10-Mar-21

Protein chain

P62942  (FKB1A_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1A from Homo sapiens

Seq: 108 a.a.

Struc: 107 a.a.

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Cell Chem Biol 0: (2021)

PubMed id: 33894161

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

m.h.larraufie, x.gao, x.xia, p.j.devine, d.liu, a.harsch, j.kallen, n.savage, j.ding, k.tan, m.mihalic, p.krastel, g.michaud, m.salcius, a.izaac, j.gao, f.harbinski, s.roggos.canham, s.bushell, e.altinoglu, p.lustenberger, e.willic.fryer, f.cong, l.klickstein, j.tallarico, r.jain, d.m.ros.wang.

ABSTRACT

No abstract given.