PDBsum entry 6y9r

Transferase

PDB id: 6y9r

Contents

Protein chain

350 a.a.

Ligands

OH8

ACT

GOL ×2

Waters ×133

PDB id:

6y9r

Name:

Transferase

Title:

Crystal structure of gsk-3b in complex with the 1h-indazole-3- carboxamide inhibitor 2

Structure:

Glycogen synthase kinase-3 beta. Chain: a. Fragment: kinase domain. Synonym: gsk-3 beta,serine/threonine-protein kinase gsk3b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.08Å R-factor: 0.191 R-free: 0.226

Authors:

S.Krapp,A.Griessner,M.Blaesse,R.Buonfiglio,R.Ombrato

Key ref:

R.Buonfiglio et al. (2020). Discovery of novel imidazopyridine gsk-3 beta inhibit supported by computational approaches.. Molecules, 25, . PubMed id: 32380735

Date:

10-Mar-20 Release date: 20-May-20

Protein chain

P49841  (GSK3B_HUMAN) -  Glycogen synthase kinase-3 beta from Homo sapiens

Seq: 420 a.a.

Struc: 350 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
• Enzyme class 2: E.C.2.7.11.26 - [tau protein] kinase.
• Reaction:
  1. L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H⁺
  2. L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site