PDBsum entry 6xed

Hydrolase

PDB id: 6xed

Contents

Protein chain

297 a.a.

Ligands

WO4

BEN ×2

TRS

Metals

_MG ×4

Waters ×290

PDB id:

6xed

Name:

Hydrolase

Title:

Crystal structure of the ptp1b yoph wpd loop chimera 3 bound to tungstate

Structure:

Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Synonym: protein-tyrosine phosphatase 1b,ptp-1b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn1, ptp1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.80Å R-factor: 0.158 R-free: 0.179

Authors:

K.J.Olsen,R.Shen,S.J.Johnson,A.C.Hengge

Key ref:

R.Shen et al. Insights from ptp1b yoph chimeras into the importance wpd-Loop sequence for activity and structure in prote tyrosine phosphatases. To be published, . PubMed id: 36507179

Date:

12-Jun-20 Release date: 15-Dec-21

Protein chain

P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1 from Homo sapiens

Seq: 435 a.a.

Struc: 297 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site