PDBsum entry 6x8h

Hydrolase/hydrolase inhibitor

PDB id: 6x8h

Contents

Protein chains

152 a.a.

89 a.a.

Ligands

ACE-1MH-ASP-B3L-PHE-Y1Y

Waters ×211

PDB id:

6x8h

Name:

Hydrolase/hydrolase inhibitor

Title:

Caspase-8 in complex with aomk inhibitor, ac-dw3-ke, forms tetrahedral adduct

Structure:

Caspase-8. Chain: a. Fragment: p18 (unp residues 276-443). Synonym: casp-8,apoptotic cysteine protease,apoptotic protease mch-5, cap4,fadd-homologous ice/ced-3-like protease,fadd-like ice,flice,ice- like apoptotic protease 5,mort1-associated ced-3 homolog,mach. Engineered: yes. Caspase-8. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: casp8, mch5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

1.48Å R-factor: 0.150 R-free: 0.167

Authors:

A.Solania,J.H.Xu,D.W.Wolan

Key ref:

A.Solania et al. Caspase-8 in complex with aomk inhibitor, Ac-Dw3-Ke, Tetrahedral adduct. To be published, .

Date:

01-Jun-20 Release date: 02-Jun-21

Protein chain

Q14790  (CASP8_HUMAN) -  Caspase-8 from Homo sapiens

Seq: 479 a.a.

Struc: 152 a.a.

Protein chain

Q14790  (CASP8_HUMAN) -  Caspase-8 from Homo sapiens

Seq: 479 a.a.

Struc: 89 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.22.61 - caspase-8.