PDBsum entry 6x1c

Cell cycle/inhibitor

PDB id: 6x1c

Contents

Protein chains

437 a.a.

427 a.a.

121 a.a.

328 a.a.

Ligands

GTP ×3

GDP

MES ×2

Y5J ×2

ACP

Metals

_MG ×5

_CA ×2

Waters ×104

PDB id:

6x1c

Name:

Cell cycle/inhibitor

Title:

Tubulin-rb3_sld-ttl in complex with compound 5j

Structure:

Tubulin alpha-1b chain. Chain: a, c. Synonym: alpha-tubulin ubiquitous,tubulin k-alpha-1,tubulin alpha- ubiquitous chain. Tubulin beta-2b chain. Chain: b, d. Stathmin-4. Chain: e. Synonym: stathmin-like protein b3,rb3.

Source:

Sus scrofa. Pig. Organism_taxid: 9823. Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: stmn4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.90Å R-factor: 0.175 R-free: 0.216

Authors:

S.W.White,M.Yun

Key ref:

S.Banerjee et al. (2021). X-Ray crystallography-Guided design, Antitumor effica qsar analysis of metabolically stable cyclopenta-Pyri dihydroquinoxalinone as a potent tubulin polymerizati inhibitor.. J med chem, 64, 13072. PubMed id: 34406768

Date:

18-May-20 Release date: 22-Sep-21

Protein chains

Q2XVP4  (TBA1B_PIG) -  Tubulin alpha-1B chain from Sus scrofa

Seq: 451 a.a.

Struc: 437 a.a.

Protein chains

A0A287AGU7  (A0A287AGU7_PIG) -  Tubulin beta chain from Sus scrofa

Seq: 445 a.a.

Struc: 427 a.a.

Protein chain

P63043  (STMN4_RAT) -  Stathmin-4 from Rattus norvegicus

Seq: 189 a.a.

Struc: 121 a.a.

Protein chain

E1BQ43  (E1BQ43_CHICK) -