PDBsum entry 6wl6

Transferase/inhibitor

PDB id: 6wl6

Contents

Protein chains

289 a.a.

Ligands

91A ×2

Waters ×192

PDB id:

6wl6

Name:

Transferase/inhibitor

Title:

Cocomplex structure of deoxyhypusine synthase with inhibitor 6-[(2r)- 1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-4h,5h,6h,7h-thieno[2,3- c]pyridin-7-one

Structure:

Deoxyhypusine synthase. Chain: a, b. Synonym: dhs. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhps, ds. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.12Å R-factor: 0.180 R-free: 0.194

Authors:

M.G.Klein,G.Ambrus-Aikelin

Key ref:

Y.Tanaka et al. New series of potent allosteric inhibitors of deoxyhy synthase. Acs med chem lett, . PubMed id: 34345355

Date:

18-Apr-20 Release date: 19-Aug-20

Protein chains

P49366  (DHYS_HUMAN) -  Deoxyhypusine synthase from Homo sapiens

Seq: 369 a.a.

Struc: 289 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.46 - deoxyhypusine synthase.
• Pathway: EC 2.5.1.46
• Reaction: [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
• Cofactor: NAD(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site