PDBsum entry 6whl

Hydrolase

PDB id: 6whl

Contents

Protein chains

(+ 6 more) 246 a.a.

Ligands

GOL ×12

Waters ×529

PDB id:

6whl

Name:

Hydrolase

Title:

The crystal structure of a beta-lactamase from legionella pneumophila str. Paris

Structure:

Beta-lactamase. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Engineered: yes

Source:

Legionella pneumophila. Organism_taxid: 297246. Strain: paris. Gene: bla, nctc12000_01749. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.166 R-free: 0.208

Authors:

K.Tan,R.Wu,M.Endres,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

K.Tan et al. The crystal structure of a beta-Lactamase from legion pneumophila str. Paris. To be published, .

Date:

08-Apr-20 Release date: 22-Apr-20

Protein chains

A0A3A6V665  (A0A3A6V665_LEGPN) -  Beta-lactamase from Legionella pneumophila subsp. pneumophila

Seq: 266 a.a.

Struc: 246 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)