PDBsum entry 6wc8

Transferase/transferase inhibitor

PDB id: 6wc8

Contents

Protein chain

138 a.a.

Ligands

TQM

SO4 ×4

Metals

IOD ×4

Waters ×26

PDB id:

6wc8

Name:

Transferase/transferase inhibitor

Title:

HIV integrase core domain in complex with inhibitor 2-(5-(3- fluorophenyl)-2-(2-(thiophen-2-yl)ethynyl)-1- benzofuran-3-yl) ethanoic acid

Structure:

Integrase. Chain: a. Fragment: unp residues 50-212. Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.88Å R-factor: 0.242 R-free: 0.278

Authors:

M.A.Gorman,M.W.Parker

Key ref:

M.A.Gorman and m.w.parker Hiv integrase core domain in complex with inhibitor. To be published, .

Date:

29-Mar-20 Release date: 31-Mar-21

Protein chain

F2WR52  (F2WR52_HV1) -  Integrase (Fragment) from Human immunodeficiency virus type 1

Seq: 288 a.a.

Struc: 138 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.7.- - ?????