PDBsum entry 6vqm

Transferase

PDB id: 6vqm

Contents

Protein chains

267 a.a.

Ligands

R7P ×2

SO4

PDB id:

6vqm

Name:

Transferase

Title:

Crystal structure analysis of human ack1

Structure:

Activated cdc42 kinase 1. Chain: a, b. Synonym: ack-1,tyrosine kinase non-receptor protein 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.87Å R-factor: 0.273 R-free: 0.330

Authors:

H.-S.Seo,S.Dhe-Paganon

Key ref:

H.-S.Seo and s.dhe-paganon Crystal structure analysis of human ack1. To be published, .

Date:

05-Feb-20 Release date: 10-Feb-21

Protein chains

Q07912  (ACK1_HUMAN) -  Activated CDC42 kinase 1 from Homo sapiens

Seq: 1038 a.a.

Struc: 267 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺
• Enzyme class 3: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site