PDBsum entry 6vlh

Transferase

PDB id: 6vlh

Contents

Protein chains

137 a.a.

136 a.a.

Ligands

SO4 ×9

R2A

Metals

IOD ×6

Waters ×54

PDB id:

6vlh

Name:

Transferase

Title:

HIV integrase core domain (in) in complex with dimer-spanning ligand

Structure:

Integrase. Chain: a, b. Fragment: core domain (unp residues 50-211). Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.04Å R-factor: 0.223 R-free: 0.298

Authors:

M.A.Gorman,M.W.Parker

Key ref:

M.Scanlon and m.a.gorman Hiv integrase core domain (in) in complex with dimeri spanning inhibitor. To be published, .

Date:

24-Jan-20 Release date: 27-Jan-21

Protein chain

F2WR39  (F2WR39_HV1) -  Integrase (Fragment) from Human immunodeficiency virus type 1

Seq: 288 a.a.

Struc: 137 a.a.*

Protein chain

F2WR39  (F2WR39_HV1) -  Integrase (Fragment) from Human immunodeficiency virus type 1

Seq: 288 a.a.

Struc: 136 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.7.49 - RNA-directed Dna polymerase.
• Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site