PDBsum entry 6v0y

Immune system

PDB id: 6v0y

Contents

Protein chains

175 a.a.

179 a.a.

13 a.a.

205 a.a.

242 a.a.

Ligands

NAG ×3

GOL ×4

Waters ×57

PDB id:

6v0y

Name:

Immune system

Title:

Immune receptor complex

Structure:

Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-4 beta chain. Chain: b. Synonym: mhc class ii antigen drb1 4,Dr4. Engineered: yes. Fibrinogen beta 72,74cit69-81.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: hla-drb1. Synthetic: yes. Mus musculus.

Resolution:

2.70Å R-factor: 0.221 R-free: 0.247

Authors:

J.J.Lim,J.Rossjohn

Key ref:

j.j.lim and j.rossjohn (2021). The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR. Sci Immunol, 6, . PubMed id: 33863750

Date:

19-Nov-19 Release date: 25-Nov-20

Protein chain

P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain from Homo sapiens

Seq: 254 a.a.

Struc: 175 a.a.

Protein chain

P01911  (2B1F_HUMAN) -  HLA class II histocompatibility antigen, DRB1 beta chain from Homo sapiens

Seq: 266 a.a.

Struc: 179 a.a.*

Protein chain

P02675  (FIBB_HUMAN) -  Fibrinogen beta chain from Homo sapiens

Seq: 491 a.a.

Struc: 13 a.a.*

Protein chain

No UniProt id for this chain

Struc: 205 a.a.

Protein chain

No UniProt id for this chain

Struc: 242 a.a.

* PDB and UniProt seqs differ at 19 residue positions (black crosses)

Sci Immunol 6: (2021)

PubMed id: 33863750

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.

j.j.lim, j.rossjohn.

ABSTRACT

No abstract given.