PDBsum entry 6u3b

Calcium-binding protein/membrane protein

PDB id: 6u3b

Contents

Protein chains

146 a.a.

34 a.a.

Metals

_CA ×5

Waters ×159

PDB id:

6u3b

Name:

Calcium-binding protein/membrane protein

Title:

1.7 angstrom crystal structure of the q135p ca-cam:cav1.2 iq domain complex

Structure:

Calmodulin-1. Chain: a. Engineered: yes. Mutation: yes. Voltage-dependent l-type calcium channel subunit alpha-1c. Chain: b. Synonym: calcium channel, l type, alpha-1 polypeptide, isoform 1, cardiac muscle, voltage-gated calcium channel subunit alpha cav1.2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: calm1, calm, cam, cam1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cacna1c, cach2, cacn2, cacnl1a1, cchl1a1. Expression_system_taxid: 562

Resolution:

1.70Å R-factor: 0.173 R-free: 0.200

Authors:

K.Wang,F.Van Petegem

Key ref:

K.Wang et al. (2020). Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca²⁺ binding and cause misfolding. J Physiol, 598, 1169-1186. PubMed id: 32012279 DOI: 10.1113/JP279307

Date:

21-Aug-19 Release date: 19-Feb-20

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 146 a.a.*

Protein chain

Q13936  (CAC1C_HUMAN) -  Voltage-dependent L-type calcium channel subunit alpha-1C from Homo sapiens

Seq: 2221 a.a.

Struc: 34 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

DOI no: 10.1113/JP279307

J Physiol 598:1169-1186 (2020)

PubMed id: 32012279

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca²⁺ binding and cause misfolding.

K.Wang, M.Brohus, C.Holt, M.T.Overgaard, R.Wimmer, F.Van Petegem.

ABSTRACT

No abstract given.