PDBsum entry 6tuh

Transferase

PDB id: 6tuh

Contents

Protein chains

157 a.a.

147 a.a.

Ligands

NXT ×5

Metals

_ZN ×4

_MG

Waters ×80

PDB id:

6tuh

Name:

Transferase

Title:

Ph domain of bruton's tyrosine kinase bound to compound 1

Structure:

Tyrosine-protein kinase btk. Chain: a, b, c, d. Fragment: ph domain and btk motif. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.25Å R-factor: 0.238 R-free: 0.276

Authors:

P.Brear,J.Wagstaff,M.Hyvonen

Key ref:

P.Brear et al. Crystal structure of 1-Methylindoline-2,3-Dione coval bound to the ph domain of bruton'S tyrosine kinase mu r28c. To be published, .

Date:

07-Jan-20 Release date: 25-Nov-20

Protein chains

Q06187  (BTK_HUMAN) -  Tyrosine-protein kinase BTK from Homo sapiens

Seq: 659 a.a.

Struc: 157 a.a.*

Protein chains

Q06187  (BTK_HUMAN) -  Tyrosine-protein kinase BTK from Homo sapiens

Seq: 659 a.a.

Struc: 147 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site