PDBsum entry 6tt2

Transferase

PDB id: 6tt2

Contents

Protein chains

164 a.a.

Metals

_ZN ×2

_MG ×2

Waters ×243

PDB id:

6tt2

Name:

Transferase

Title:

The ph domain of bruton's tyrosine kinase mutant r28c

Structure:

Tyrosine-protein kinase btk. Chain: a, b. Fragment: ph domain and btk motif. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.36Å R-factor: 0.205 R-free: 0.234

Authors:

P.Brear,J.Wagstaff,M.Hyvonen

Key ref:

P.Brear et al. Crystal structure of 1-Methylindoline-2,3-Dione coval bound to the ph domain of bruton'S tyrosine kinase mu r28c. To be published, .

Date:

23-Dec-19 Release date: 25-Nov-20

Protein chains

Q06187  (BTK_HUMAN) -  Tyrosine-protein kinase BTK from Homo sapiens

Seq: 659 a.a.

Struc: 164 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site