PDBsum entry 6tls

Transferase

PDB id: 6tls

Contents

Protein chain

333 a.a.

Ligands

NL2 ×2

_CL ×5

PEG

Metals

_NA

Waters ×590

PDB id:

6tls

Name:

Transferase

Title:

Human ck2 kinase alpha subunit in complex with the atp-competitive inhibitor 4,6-dibromobenzotriazole

Structure:

Casein kinase ii subunit alpha. Chain: a. Synonym: ck ii alpha. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1, ck2a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.46Å R-factor: 0.155 R-free: 0.173

Authors:

H.Czapinska,A.Piasecka,M.Winiewska-Szajewska,M.Bochtler,J.Poznanski

Key ref:

H.Czapinska et al. Binding of bromobenzotriazoles by the catalytic subun human protein kinase ck2: structural and thermodynami studies.. To be published, . PubMed id: 33689348

Date:

03-Dec-19 Release date: 16-Dec-20

Protein chain

P68400  (CSK21_HUMAN) -  Casein kinase II subunit alpha from Homo sapiens

Seq: 391 a.a.

Struc: 333 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site