PDBsum entry 6tb2

Metal transport

PDB id: 6tb2

Contents

Protein chains

141 a.a.

146 a.a.

256 a.a.

333 a.a.

Ligands

HEM ×2

PDB id:

6tb2

Name:

Metal transport

Title:

Structure of human haptoglobin-hemoglobin bound to s. Aureus isdh

Structure:

Hemoglobin subunit alpha. Chain: a. Synonym: alpha-globin,hemoglobin alpha chain. Hemoglobin subunit beta. Chain: b. Synonym: beta-globin,hemoglobin beta chain. Haptoglobin. Chain: c. Synonym: zonulin.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hp. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho. Staphylococcus aureus. Organism_taxid: 1280.

Resolution:

2.90Å R-factor: 0.237 R-free: 0.270

Authors:

J.H.Mikkelsen,C.B.F.Andersen

Key ref:

J.H.Mikkelsen et al. Haptoglobin is an inhibitor of staphylococcus aureus isdh-Mediated heme-Sequestering. To be published, .

Date:

31-Oct-19 Release date: 18-Dec-19

Protein chain

P69905  (HBA_HUMAN) -  Hemoglobin subunit alpha from Homo sapiens

Seq: 142 a.a.

Struc: 141 a.a.

Protein chain

P68871  (HBB_HUMAN) -  Hemoglobin subunit beta from Homo sapiens

Seq: 147 a.a.

Struc: 146 a.a.

Protein chain

P00738  (HPT_HUMAN) -  Haptoglobin from Homo sapiens

Seq: 406 a.a.

Struc: 256 a.a.*

Protein chains

Q2FXJ2  (ISDH_STAA8) -  Iron-regulated surface determinant protein H from Staphylococcus aureus (strain NCTC 8325 / PS 47)

Seq: 895 a.a.

Struc: 333 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)