PDBsum entry 6t5k

Antimicrobial protein

PDB id: 6t5k

Contents

Protein chain

224 a.a.

Ligands

EDO ×5

Metals

_ZN ×2

Waters ×254

PDB id:

6t5k

Name:

Antimicrobial protein

Title:

Ecv-1 from echinicola vietnamensis. Environmental metallo-beta- lactamases exhibit high enzymatic activity under zinc deprivation

Structure:

Zn-dependent hydrolase, glyoxylase. Chain: c. Engineered: yes

Source:

Echinicola vietnamensis. Organism_taxid: 390884. Gene: echvi_2632. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.33Å R-factor: 0.149 R-free: 0.184

Authors:

C.Frohlich

Key ref:

C.Fröhlich et al. (2020). Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. J Antimicrob Chemother, 75, 2554-2563. PubMed id: 32464640 DOI: 10.1093/jac/dkaa175

Date:

16-Oct-19 Release date: 27-May-20

Protein chain

L0FY79  (L0FY79_ECHVK) -  Metallo-beta-lactamase type 2 from Echinicola vietnamensis (strain DSM 17526 / LMG 23754 / KMM 6221)

Seq: 257 a.a.

Struc: 224 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)

DOI no: 10.1093/jac/dkaa175

J Antimicrob Chemother 75:2554-2563 (2020)

PubMed id: 32464640

Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1.

C.Fröhlich, V.Sørum, S.Huber, Ã.˜.Samuelsen, F.Berglund, E.Kristiansson, S.D.Kotsakis, N.P.Marathe, D.G.J.Larsson, H.S.Leiros.

ABSTRACT

No abstract given.