PDBsum entry 6t3m

Hydrolase

PDB id: 6t3m

Contents

Protein chains

30 a.a.

251 a.a.

Ligands

ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYS-LEU

NAG

MD8 ×2

PO4

Metals

_NA ×2

Waters ×248

PDB id:

6t3m

Name:

Hydrolase

Title:

Thrombin in complex with a d-phe-pro-p-phenol derivative

Structure:

Prothrombin. Chain: l. Synonym: coagulation factor ii. Prothrombin. Chain: h. Synonym: coagulation factor ii. Hirudin variant-2. Chain: i. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421

Resolution:

1.38Å R-factor: 0.134 R-free: 0.158

Authors:

K.Ngo,C.Collins,A.Heine,G.Klebe

Key ref:

K.Ngo et al. Thrombin in complex with a d-Phe-Pro-P-Phenol derivat. To be published, .

Date:

11-Oct-19 Release date: 18-Nov-20

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 30 a.a.

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 251 a.a.

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.5 - thrombin.
• Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.