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PDBsum entry 6t37
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PDB id:
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Transferase
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Title:
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Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
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Structure:
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Glucose-1-phosphate thymidylyltransferase. Chain: a, b, c, d. Engineered: yes. Other_details: residues missing from the model are due to flexibility and weak electron density
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Source:
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Pseudomonas aeruginosa. Organism_taxid: 287. Gene: rmla, rfba, caz10_00575, e4v10_15605, ipc1492_24235, ipc605_02475, pamh19_2921. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.08Å
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R-factor:
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0.219
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R-free:
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0.242
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Authors:
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M.S.Alphey,G.Xiao,J.N.Westwood
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Key ref:
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G.Xiao
et al.
Potent allosteric inhibitors of pseudomonas aeruginos glucose-1-Phosphate thymidylyltransferase (rmla).
To be published,
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PubMed id:
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Date:
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10-Oct-19
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Release date:
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19-Aug-20
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PROCHECK
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Headers
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References
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Q9HU22
(Q9HU22_PSEAE) -
Glucose-1-phosphate thymidylyltransferase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
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Seq:
Struc:
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293 a.a.
289 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.7.24
- glucose-1-phosphate thymidylyltransferase.
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Pathway:
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6-Deoxyhexose Biosynthesis
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Reaction:
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dTTP + alpha-D-glucose 1-phosphate + H+ = dTDP-alpha-D-glucose + diphosphate
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dTTP
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+
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alpha-D-glucose 1-phosphate
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+
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H(+)
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=
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dTDP-alpha-D-glucose
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+
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diphosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
