PDBsum entry 6t35

Hydrolase

PDB id: 6t35

Contents

Protein chain

358 a.a.

Ligands

SO4

PEG ×2

M9W

Metals

_CL

_ZN ×3

Waters ×258

PDB id:

6t35

Name:

Hydrolase

Title:

Crystal structure of ampc from e.Coli with enmetazobactam (aai-101)

Structure:

Beta-lactamase. Chain: a. Synonym: cephalosporinase. Engineered: yes

Source:

Escherichia coli k-12. Organism_taxid: 83333. Gene: ampc, ampa, b4150, jw4111. Expressed in: escherichia coli str. K-12 substr. W3110. Expression_system_taxid: 316407

Resolution:

1.75Å R-factor: 0.168 R-free: 0.184

Authors:

P.A.Lang,T.M.Leissing,C.J.Schofield,J.Brem

Key ref:

P.A.Lang et al. Crystal structure of ampc from e.Coli with enmetazoba (aai-101). To be published, . PubMed id: 35486701

Date:

10-Oct-19 Release date: 18-Nov-20

Protein chain

P00811  (AMPC_ECOLI) -  Beta-lactamase from Escherichia coli (strain K12)

Seq: 377 a.a.

Struc: 358 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)