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PDBsum entry 6s1h
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PDB id:
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Transferase
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Title:
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Crystal structure of dyrk1a with small molecule inhibitor
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Structure:
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Dual specificity tyrosine-phosphorylation-regulated kinase 1a. Chain: a. Synonym: dual specificity yak1-related kinase,hp86,protein kinase minibrain homolog,hmnb. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: dyrk1a, dyrk, mnb, mnbh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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1.05Å
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R-factor:
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0.141
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R-free:
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0.155
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Authors:
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F.J.Sorrell,S.H.Henderson,C.Redondo,N.A.Burgess-Brown,F.Von Delft, C.H.Arrowsmith,C.Bountra,A.M.Edwards,J.M.Elkins
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Key ref:
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F.J.Sorrell
et al.
Kinase scaffold repurposing in the public domain.
To be published,
.
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Date:
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18-Jun-19
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Release date:
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26-Jun-19
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PROCHECK
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Headers
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References
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Q13627
(DYR1A_HUMAN) -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A from Homo sapiens
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Seq:
Struc:
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763 a.a.
340 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.2.7.11.23
- [RNA-polymerase]-subunit kinase.
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Reaction:
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[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H+
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[DNA-directed RNA polymerase]
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+
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ATP
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=
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phospho-[DNA-directed RNA polymerase]
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+
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ADP
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+
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H(+)
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Enzyme class 3:
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E.C.2.7.12.1
- dual-specificity kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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3.
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
