PDBsum entry 6ron

Hydrolase

PDB id: 6ron

Contents

Protein chain

330 a.a.

Ligands

KCE

GOL

DMS ×2

Waters ×330

PDB id:

6ron

Name:

Hydrolase

Title:

Endothiapepsin in complex with compound 046

Structure:

Endothiapepsin. Chain: a. Synonym: aspartate protease. Ec: 3.4.23.22

Source:

Cryphonectria parasitica. Chestnut blight fungus. Organism_taxid: 5116

Resolution:

1.15Å R-factor: 0.135 R-free: 0.153

Authors:

F.Magari,A.Heine,G.Klebe

Key ref:

F.Magari et al. Endothiapepsin in complex with compound 046. To be published, .

Date:

13-May-19 Release date: 08-Jul-20

Protein chain

P11838  (CARP_CRYPA) -  Endothiapepsin from Cryphonectria parasitica

Seq: 419 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.22 - endothiapepsin.
• Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.