PDBsum entry 6rfh

Lyase

PDB id: 6rfh

Contents

Protein chain

257 a.a.

Ligands

BGC

BE7

4SO ×3

Metals

_ZN

_HG

Waters ×267

PDB id:

6rfh

Name:

Lyase

Title:

Human carbonic anhydrase ii in complex with 4- carboxybenzenesulfonamide

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii,carbonic anhydrasE C,cac,carbonic anhydrase ii,ca-ii. Engineered: yes. Other_details: the first 5 amino acids (gspef) are remainders of an expression tag.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

0.97Å R-factor: 0.122 R-free: 0.136

Authors:

S.Gloeckner,A.Heine,G.Klebe

Key ref:

S.Gloeckner et al. Human carbonic anhydrase ii in complex with 4-Carboxybenzenesulfonamide. To be published, .

Date:

15-Apr-19 Release date: 13-May-20

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 257 a.a.

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site