PDBsum entry 6qwc

Antimicrobial protein

PDB id: 6qwc

Contents

Protein chain

268 a.a.

Ligands

SO4 ×8

GOL

MK7

Waters ×255

PDB id:

6qwc

Name:

Antimicrobial protein

Title:

Crystal structure of kpc-4 complexed with relebactam (1 hour soak)

Structure:

Beta-lactamase. Chain: a. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: blakpc-4, blakpc-2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.30Å R-factor: 0.142 R-free: 0.164

Authors:

C.L.Tooke,P.Hinchliffe,J.Spencer

Key ref:

C.L.Tooke et al. Molecular basis of class a beta-Lactamase inhibition relebactam.. Antimicrob agents chemother, . PubMed id: 31383664

Date:

05-Mar-19 Release date: 21-Aug-19

Protein chain

Q9F663  (BLKPC_KLEPN) -  Carbapenem-hydrolyzing beta-lactamase KPC from Klebsiella pneumoniae

Seq: 293 a.a.

Struc: 268 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)