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PDBsum entry 6qgo
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PDB id:
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Hydrolase
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Title:
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Crystal structure of apt1 s119a mutant bound to palmitic acid.
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Structure:
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Acyl-protein thioesterase 1. Chain: b, c. Synonym: hapt1,lysophospholipase 1,lysophospholipase i,lysopla i. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: lypla1, apt1, lpl1. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.60Å
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R-factor:
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0.190
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R-free:
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0.236
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Authors:
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M.Audagnotto,M.J.Marcaida,S.Ho,F.Pojer,G.Van Der Goot,M.Dal Peraro
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Date:
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12-Jan-19
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Release date:
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05-Feb-20
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PROCHECK
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Headers
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References
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O75608
(LYPA1_HUMAN) -
Acyl-protein thioesterase 1 from Homo sapiens
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Seq:
Struc:
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230 a.a.
221 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class 2:
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E.C.3.1.2.-
- ?????
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Enzyme class 3:
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E.C.3.1.2.22
- palmitoyl-protein hydrolase.
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Reaction:
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S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H+
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S-hexadecanoyl-L-cysteinyl-[protein]
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+
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H2O
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=
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L-cysteinyl-[protein]
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+
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hexadecanoate
Bound ligand (Het Group name = )
corresponds exactly
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
