PDBsum entry 6q7c

Transferase

PDB id: 6q7c

Contents

Protein chain

277 a.a.

Ligands

HOK

Waters ×353

PDB id:

6q7c

Name:

Transferase

Title:

Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl11

Structure:

Ephrin type-a receptor 2. Chain: a. Synonym: epithelial cell kinase,tyrosine-protein kinase receptor eck. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.05Å R-factor: 0.193 R-free: 0.212

Authors:

D.Kudlinzki,A.Troester,K.Witt,V.L.Linhard,S.L.Gande,K.Saxena, H.Schwalbe

Key ref:

A.Troester et al. Effects of nvp-Bhg712 chemical modifications on epha2 binding and affinity. To be published, .

Date:

13-Dec-18 Release date: 15-Jan-20

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 277 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site