PDBsum entry 6pwm

Hydrolase

PDB id: 6pwm

Contents

Protein chains

356 a.a.

Ligands

CAZ ×4

GLY

Waters ×176

PDB id:

6pwm

Name:

Hydrolase

Title:

Adc-7 in complex with beta-lactam antibiotic ceftazidime

Structure:

Beta-lactamase. Chain: a, b, c, d. Engineered: yes

Source:

Acinetobacter baumannii. Organism_taxid: 470. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.40Å R-factor: 0.216 R-free: 0.254

Authors:

B.C.Curtis,R.A.Powers,B.J.Wallar

Key ref:

B.N.Curtis et al. Structural insights into inhibition of the acinetobac derived cephalosporinase adc-7 by ceftazidime and its boronic acid transition state analog.. Antimicrob agents chemother, . PubMed id: 32988830

Date:

23-Jul-19 Release date: 21-Oct-20

Protein chains

Q6DRA1  (Q6DRA1_ACIBA) -  Beta-lactamase from Acinetobacter baumannii

Seq: 383 a.a.

Struc: 356 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)