PDBsum entry 6pcw

Transferase/transferase inhibitor

PDB id: 6pcw

Contents

Protein chain

273 a.a.

Ligands

ARG-LYS-ARG-ARG-ARG-HIS-PRO-SER

O97

GOL ×2

Waters ×67

PDB id:

6pcw

Name:

Transferase/transferase inhibitor

Title:

Human pim1 bound to benzothiophene inhibitor 213

Structure:

Serine/threonine-protein kinase pim-1. Chain: a. Engineered: yes. Peptide. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

2.20Å R-factor: 0.177 R-free: 0.226

Authors:

P.H.C.Godoi,A.S.Santiago,A.M.Fala,P.Z.Ramos,D.Sriranganadane, A.Mascarello,N.Segretti,H.Azevedo,C.R.W.Guimaraes,P.Arruda, J.M.Elkins,R.M.Counago,Structural Genomics Consortium (Sgc)

Key ref:

P.H.C.Godoi et al. Pim1 bound to benzothiophene inhibitor. To be published, .

Date:

18-Jun-19 Release date: 24-Jul-19

Protein chain

P11309  (PIM1_HUMAN) -  Serine/threonine-protein kinase pim-1 from Homo sapiens

Seq: 313 a.a.

Struc: 273 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site