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PDBsum entry 6odc
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PDB id:
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Hydrolase
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Title:
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Crystal structure of hdac8 in complex with compound 30
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Structure:
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Histone deacetylase 8. Chain: a, b, c. Synonym: hd8. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hdac8, hdacl1, cda07. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.80Å
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R-factor:
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0.196
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R-free:
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0.236
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Authors:
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X.Zheng,C.Conti,J.Caravella,M.-M.Zablocki,K.Bair,N.Barczak,B.Han, D.Lancia Jr.,C.Liu,M.Martin,P.Y.Ng,A.Rudnitskaya,J.J.Thomason, R.Garcia-Dancey,C.Hardy,J.Lahdenranta,C.Leng,P.Li,E.Pardo, A.Saldahna,T.Tan,A.V.Toms,L.Yao,C.Zhang
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Date:
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26-Mar-19
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Release date:
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01-Apr-20
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PROCHECK
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Headers
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References
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Q9BY41
(HDAC8_HUMAN) -
Histone deacetylase 8 from Homo sapiens
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Seq:
Struc:
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377 a.a.
367 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.3.5.1.98
- histone deacetylase.
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Reaction:
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N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
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N(6)-acetyl-L-lysyl-[histone]
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+
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H2O
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=
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L-lysyl-[histone]
Bound ligand (Het Group name = )
matches with 60.00% similarity
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+
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acetate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
