PDBsum entry 6l2c

Transferase

PDB id: 6l2c

Contents

Protein chains

402 a.a.

Ligands

COA ×4

Waters ×231

PDB id:

6l2c

Name:

Transferase

Title:

Crystal structure of aspergillus fumigatus mitochondrial acetyl-coa acetyltransferase in complex with coa

Structure:

Acetyl-coa-acetyltransferase, putative. Chain: a, b, c, d. Engineered: yes

Source:

Aspergillus fumigatus a1163. Organism_taxid: 451804. Strain: a1163. Gene: afub_000550. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

2.44Å R-factor: 0.206 R-free: 0.257

Authors:

Y.Zhang,W.Wei,O.G.Raimi,A.T.Ferenbach,W.Fang

Key ref:

Y.Zhang et al. Characterization ofaspergillus fumigatusmitochondrial acetyl-Coa acetyltransferase as an antifungal target.. Appl environ microbiol, . PubMed id: 32005728

Date:

03-Oct-19 Release date: 12-Feb-20

Protein chains

B0XMC1  (ER10A_ASPFC) -  Acetyl-CoA acetyltransferase erg10A, mitochondrial from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)

Seq: 433 a.a.

Struc: 402 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.3.1.9 - acetyl-CoA C-acetyltransferase.
• Pathway: Mevalonate Biosynthesis
• Reaction: 2 acetyl-CoA = acetoacetyl-CoA + CoA

2 × acetyl-CoA = acetoacetyl-CoA + CoA (Bound ligand (Het Group name = COA) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site