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PDBsum entry 6irc
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PDB id:
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Hydrolase
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Title:
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C-terminal domain of drosophila phospholipase b norpa, methylated
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Structure:
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase. Chain: a. Synonym: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta,no receptor potential a protein,phosphoinositide phospholipase c,phosphoinositide phospholipasE C-beta. Engineered: yes
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Source:
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Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: norpa, plc-beta, cg3620. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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3.54Å
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R-factor:
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0.247
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R-free:
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0.296
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Authors:
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F.Ye,J.Li,Y.Huang,W.Liu,M.Zhang
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Key ref:
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f.ye
et al.
(2018).
An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
Elife,
7,
.
PubMed id:
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Date:
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12-Nov-18
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Release date:
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02-Jan-19
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PROCHECK
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Headers
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References
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P13217
(PIPA_DROME) -
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase from Drosophila melanogaster
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Seq:
Struc:
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1095 a.a.
211 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.4.11
- phosphoinositide phospholipase C.
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Pathway:
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myo-Inositol Phosphate Metabolism
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
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+
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H2O
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=
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1D-myo-inositol 1,4,5-trisphosphate
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+
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1,2-diacyl-sn-glycerol
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Elife
7:
(2018)
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PubMed id:
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An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
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f.ye,
j.li,
z.liu,
m.zhang.
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ABSTRACT
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Links
