PDBsum entry 6ei2

Immune system

PDB id: 6ei2

Contents

Protein chains

275 a.a.

100 a.a.

Ligands

GLU-THR-SER-PRO-LEU-THR-ALA-GLU-LYS-LEU

EDO ×6

Metals

_NI ×3

_CD ×2

_CO

Waters ×442

PDB id:

6ei2

Name:

Immune system

Title:

Crystal structure of hla-a68 presenting a c-terminally extended peptide

Structure:

Hla class i histocompatibility antigen, a-68 alpha chain. Chain: a. Synonym: aw-68,hla class i histocompatibility antigen,a-28 alpha chain,mhc class i antigen a 68. Engineered: yes. Beta-2-microglobulin. Chain: b. Engineered: yes. G1/s-specific cyclin-d2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.

Resolution:

1.61Å R-factor: 0.159 R-free: 0.181

Authors:

S.Picaud,P.Guillaume,A.C.W.Pike,F.Von Delft,C.H.Arrowsmith, A.M.Edwards,C.Bountra,D.Gfeller,P.Filippakopoulos

Key ref:

S.Picaud et al. Crystal structure of hla-A68 presenting a c-Terminall extended peptide. To be published, .

Date:

16-Sep-17 Release date: 11-Oct-17

Protein chain

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)