PDBsum entry 6dir

Hydrolase/hydrolase inhibitor

PDB id: 6dir

Contents

Protein chain

198 a.a.

Ligands

GKA

SO4 ×2

Metals

_ZN

Waters ×232

PDB id:

6dir

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of hcv ns3/4a protease in complex with p4-p5-2 (aj- 67)

Structure:

Ns3 protease. Chain: a. Engineered: yes

Source:

Hepacivirus c. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.75Å R-factor: 0.148 R-free: 0.193

Authors:

A.N.Matthew,C.A.Schiffer

Key ref:

A.N.Matthew and c.a.schiffer Design of hepatitis c ns3/4a protease inhibitors leve untapped regions of the substrate envelope. To be published, .

Date:

23-May-18 Release date: 31-Jul-19

Protein chain

A0A0B4WYC6  (A0A0B4WYC6_9HEPC) -  Genome polyprotein (Fragment) from Hepacivirus C

Seq: 182 a.a.

Struc: 198 a.a.*

* PDB and UniProt seqs differ at 13 residue positions (black crosses)