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PDBsum entry 6cve
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PDB id:
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| Name: |
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Transferase
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Title:
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Crystal structure of mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate and 7,8- diaminopelargonic acid
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Structure:
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Atp-dependent dethiobiotin synthetase biod. Chain: a, b, c, d. Synonym: dtb synthetase,dtbs,dethiobiotin synthase. Engineered: yes
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Source:
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Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: biod, rv1570, mtcy336.33c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.20Å
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R-factor:
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0.198
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R-free:
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0.271
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Authors:
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A.P.Thompson,J.B.Bruning,K.L.Wegener,S.W.Polyak
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Key ref:
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A.P.Thompson
et al.
(2018).
Mycobacterium tuberculosis dethiobiotin synthetase facilitates nucleoside triphosphate promiscuity throu alternate binding modes.
Acs catalysis,
11,
10774.
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Date:
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28-Mar-18
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Release date:
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21-Nov-18
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PROCHECK
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Headers
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References
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P9WPQ5
(BIOD_MYCTU) -
Dethiobiotin synthetase BioD from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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Seq:
Struc:
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226 a.a.
227 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.6.3.3.3
- dethiobiotin synthase.
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Reaction:
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(7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H+
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(7R,8S)-7,8-diammoniononanoate
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+
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CO2
Bound ligand (Het Group name = )
matches with 87.50% similarity
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ATP
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=
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(4R,5S)-dethiobiotin
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+
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ADP
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+
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phosphate
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+
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3
×
H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
