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PDBsum entry 6cb0
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PDB id:
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Transferase
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Title:
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Crystal structure of the fak ferm domain
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Structure:
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Focal adhesion kinase 1. Chain: a, b. Synonym: fadk 1,focal adhesion kinase-related nonkinase,p41/p43frnk, protein-tyrosine kinase 2,p125fak,pp125fak. Engineered: yes
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Source:
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Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.97Å
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R-factor:
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0.173
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R-free:
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0.212
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Authors:
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A.Dementiev,T.Marlowe
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Key ref:
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T.Marlowe
et al.
(2019).
High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site.
BMC Mol Cell Biol,
20,
10.
PubMed id:
DOI:
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Date:
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01-Feb-18
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Release date:
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06-Feb-19
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PROCHECK
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Headers
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References
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Q00944
(FAK1_CHICK) -
Focal adhesion kinase 1 from Gallus gallus
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Seq:
Struc:
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1053 a.a.
357 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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BMC Mol Cell Biol
20:10
(2019)
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PubMed id:
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High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site.
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T.Marlowe,
A.Dementiev,
S.Figel,
A.Rivera,
M.Flavin,
W.Cance.
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ABSTRACT
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Links
